Dr. Domenico FIORE
V.le Madonna delle Grazie, 17
I-35028 Piove di Sacco (Padova - Italy)
AMYOTROPHIC LATERAL SCLEROSIS
Domenico Fiore, M.D. - Indipendent Professional - Piove di Sacco (PD) - Italia
Objective: Etiopathogenesis - Treatment
Subjects - Methods - Results. Having found a toxi-infection by Bordetella Pertussis in 250 patients affected by multiple sclerosis, I searched in the serum for anti-pertussis antibodies in 75 neurologic patients in whom the nuclear magnetic resonance had excluded the presence of patches (Amyotrophic Lateral Sclerosis, ALS - non-patched neuropathies, NPNs): in all these cases there was a infection from Bordetella Pertussis [in E.L.I.S.A. the research of anti-Bordetella Pertussis antibodies (total IgG and IgM; anti H.A. Filamentous and anti-Pertussis Toxin IgA and IgG) was positive].
Discussion - Conclusions. The experimental allergic encephalitis,
in a determinate animal Species, may be induced only in subjects with
astrocytes which produce II class-HLA-Antigens (anti II class-HLA Antigens
antibodies inhibit its onset); soluble Adhesion Molecules are present
in multiple sclerosis, they are not present in non-inflammatory neuropathies.
Teatment.: reclamation of mucosae and a long-term prophylaxis
of re-infections with Ethylsuccinate of Erythromycin; plasmapheresis (6-8
sittings) during the first 20 days of antibiotic treatment (to avoid a
dangerous Jarisch-Herxheimer's reaction).
References: Fiore Domenico:
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